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Association between beta-blockers, other antihypertensive drugs and psoriasis : population-based case-control study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1195898
Author(s) Brauchli, Y B; Jick, S S; Curtin, F; Meier, C R
Author(s) at UniBasel Meier, Christoph R.
Year 2008
Title Association between beta-blockers, other antihypertensive drugs and psoriasis : population-based case-control study
Journal British journal of dermatology
Volume 158
Number 6
Pages / Article-Number 1299-307
Keywords antihypertensive drugs, beta-blockers, cardiovascular risk factors, psoriasis
Abstract BACKGROUND: Several case reports have associated use of beta-blockers with an increased risk of psoriasis or psoriasiform drug eruptions. OBJECTIVES: To study the association between use of beta-blockers and other antihypertensive drugs and the risk of developing a first-time diagnosis of psoriasis. METHODS: We conducted a case-control analysis on the U.K.-based General Practice Research Database. We identified cases with an incident psoriasis diagnosis between 1994 and 2005 and matched them to one control patient on age, sex, general practice, calendar time (same index date) and years of history in the database. Conditional logistic regression was used to estimate adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of developing a first-time psoriasis diagnosis in relation to previous exposure to antihypertensive drugs, stratified by exposure timing (current vs. past use) and exposure duration based on the number of prescriptions. RESULTS: The study encompassed 36 702 cases with a first-time psoriasis diagnosis and the same number of matched controls. Adjusted ORs for current use of 1-4, 5-19 or >or= 20 prescriptions for beta-blockers, as compared with nonuse, were 0.93 (95% CI 0.76-1.13), 1.10 (95% CI 0.97-1.24), and 1.10 (95% CI 1.01-1.20), respectively. The risk estimates for current use of other antihypertensives at any exposure duration were all close to 1.0. CONCLUSIONS: This large population-based case-control analysis does not support the current proposition that beta-blocker use is associated with an increased risk of psoriasis, nor did we find evidence for a substantially altered psoriasis risk for other antihypertensive drugs.
Publisher Lewis
ISSN/ISBN 0007-0963
edoc-URL http://edoc.unibas.ch/dok/A6006077
Full Text on edoc No
Digital Object Identifier DOI 10.1111/j.1365-2133.2008.08563.x
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18410416
ISI-Number WOS:000255960300017
Document type (ISI) Journal Article
 
   

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