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Assessment of varicella vaccine effectiveness in Germany: a time-series approach.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift) |
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ID |
1195785 |
Author(s) |
Höhle,M; Siedler,A; Bader,H-M; Ludwig,M; Heininger,U; VON Kries,R |
Author(s) at UniBasel |
Heininger, Ulrich
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Year |
2011 |
Title |
Assessment of varicella vaccine effectiveness in Germany: a time-series approach. |
Journal |
EPIDEMIOL INFECT |
Volume |
139 |
Pages / Article-Number |
1710-9 |
Abstract |
SUMMARYA multivariate time-series regression model was developed in order to describe the 2005-2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1-2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83·2% (95% CI 80·2-85·7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the USA. |
ISSN/ISBN |
0950-2688 |
Full Text on edoc |
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