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Assessment of varicella vaccine effectiveness in Germany: a time-series approach.
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1195785
Author(s) Höhle,M; Siedler,A; Bader,H-M; Ludwig,M; Heininger,U; VON Kries,R
Author(s) at UniBasel Heininger, Ulrich
Year 2011
Title Assessment of varicella vaccine effectiveness in Germany: a time-series approach.
Journal EPIDEMIOL INFECT
Volume 139
Pages / Article-Number 1710-9
Abstract SUMMARYA multivariate time-series regression model was developed in order to describe the 2005-2008 age-specific time-course of varicella sentinel surveillance data following the introduction of a varicella childhood vaccination programme in Germany. This ecological approach allows the assessment of vaccine effectiveness under field conditions by relating vaccine coverage in cohorts of 24-month-old children to the mean number of cases per reporting unit in the sentinel network. For the 1-2 years age group, which is directly affected by the vaccination programme, a one-dose vaccine effectiveness of 83·2% (95% CI 80·2-85·7) was estimated which corresponds to previous approaches assessing varicella vaccine effectiveness in the field in the USA.
ISSN/ISBN 0950-2688
Full Text on edoc
   

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