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Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young man
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
1195750
Author(s)
Garcia de la Fuente, Isabel; Ansari, Marc; Rougemont, Anne-Laure; Passweg, Jakob R; Gumy-Pause, Fabienne; Ozsahin, Hulya; Lobrinus, Johannes A; Posfay-Barbe, Klara M
Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young man
Journal
Pediatric infectious disease journal
Volume
29
Number
11
Pages / Article-Number
1059-60
Abstract
We describe a case of fatal acute disseminated breakthrough toxoplasmosis in a 19-year-old adolescent after haploidentical hematopoietic stem cell transplantation for acute lymphoblastic leukemia despite continued atovaquone prophylaxis. Diagnosis was at necropsy, and confirmed by postmortem polymerase chain reaction analysis in plasma. This report illustrates the need for protozoal monitoring despite atovaquone prophylaxis, in severely immunocompromised patients with intolerance to standard treatment.
