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Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1195631
Author(s) Castro-Giner, F.; Künzli, N.; Jacquemin, B.; Forsberg, B.; de Cid, R.; Sunyer, J.; Jarvis, D.; Briggs, D.; Vienneau, D.; Norback, D.; Gonzalez, J. R.; Guerra, S.; Janson, C.; Anto, J. M.; Wjst, M.; Heinrich, J.; Estivill, X.; Kogevinas, M.
Author(s) at UniBasel Künzli, Nino
Year 2009
Title Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
Journal Environmental Health Perspectives
Volume 117
Number 12
Pages / Article-Number 1919-24
Keywords air pollution, asthma, gene polymorphisms, genetics, nitrogen dioxide, oxidative stress, traffic pollution
Abstract BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO(2) estimates were available. Home addresses were geocoded and linked to modeled outdoor NO(2) estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor alpha (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor beta2 (ADRB2)]. RESULTS: The association between modeled NO(2) and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO(2) was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO(2) for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma
Publisher National Institute of Environmental Health Sciences
ISSN/ISBN 0091-6765 ; 1552-9924
edoc-URL http://edoc.unibas.ch/dok/A5843362
Full Text on edoc Available
Digital Object Identifier DOI 10.1289/ehp.0900589
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20049212
ISI-Number WOS:000272474600035
Document type (ISI) Journal Article
 
   

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