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Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1195571
Author(s) Riener, Marc-Oliver; Fritzsche, Florian R; Soll, Christopher; Pestalozzi, Bernhard C; Probst-Hensch, Nicole; Clavien, Pierre-Alain; Jochum, Wolfram; Soltermann, Alex; Moch, Holger; Kristiansen, Glen
Author(s) at UniBasel Probst Hensch, Nicole
Year 2010
Title Expression of the extracellular matrix protein periostin in liver tumours and bile duct carcinomas
Journal Histopathology
Volume 56
Number 5
Pages / Article-Number 600-6
Keywords bile duct carcinoma, EMT, hepatocellular carcinoma, periostin, prognosis
Abstract

AIMS: To study the relevance of periostin, known to be involved in epithelial-mesenchymal transition (EMT), in hepatocellular and bile duct cancer. METHODS AND RESULTS: Immunohistochemical periostin expression was semiquantitatively analysed in normal liver tissue (n = 20), hepatocellular carcinoma (HCC; n = 91), liver-cell adenoma (n = 9), focal nodular hyperplasia (n = 13) and bile duct carcinomas (BDC; n = 116) using tissue microarrays. Normal bile ducts, gallbladder epithelium and hepatocytes showed weak cytoplasmic periostin expression. In HCC, there was strong epithelial periostin expression in 19/91 (20.9%) and strong stromal periostin expression in 10/91 cases (11%). Epithelial expression in tumour cells was significantly associated with a higher tumour grade (P < 0.05) and hepatitis B virus infection (P = 0.007). Importantly, there was no strong periostin expression in benign liver tumours. Strong stromal periostin expression was detected in 78/116 (67.2%) BDC and strong epithelial expression in 39/116 (33.6%) BDC. pT stage, differentiation grade and proliferation rate in primary BDC were independent of periostin expression. Epithelial periostin expression was associated with reduced overall survival on univariate and multivariate analysis. CONCLUSIONS: The EMT protein periostin is expressed in the stroma and epithelium of a subset of BDC and HCC. Epithelial periostin expression is a marker for malignant transformation of hepatocytes and a novel prognostic marker in BDC

Publisher Blackwell Scientific Publ.
ISSN/ISBN 0309-0167
edoc-URL http://edoc.unibas.ch/dok/A5842893
Full Text on edoc No
Digital Object Identifier DOI 10.1111/j.1365-2559.2010.03527.x
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20459570
ISI-Number WOS:000276169500005
Document type (ISI) Article
 
   

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