Mitral Annular Shape, Size, and Motion in Normals and in Patients with Cardiomyopathy : Evaluation with computed tomography
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1195485
Author(s) Alkadhi, Hatem; Desbiolles, Lotus; Stolzmann, Paul; Leschka, Sebastian; Scheffel, Hans; Plass, André; Schertler, Thomas; Trindade, Pedro Trigo; Genoni, Michele; Cattin, Philippe; Marincek, Borut; Frauenfelder, Thomas
Author(s) at UniBasel Cattin, Philippe Claude
Year 2009
Title Mitral Annular Shape, Size, and Motion in Normals and in Patients with Cardiomyopathy : Evaluation with computed tomography
Journal Investigative radiology
Volume 44
Number 4
Pages / Article-Number 218-25
Keywords mitral annulus, computed tomography, cardiomyopathy, motion
Abstract OBJECTIVE: To assess prospectively, in healthy subjects and in patients with dilated cardiomyopathy (DCM) and hypertrophic obstructive cardiomyopathy (HOCM), the 3-dimensional (3D) shape, size, and motion of the mitral annulus (MA) using computed tomography (CT). MATERIALS AND METHODS: Twenty patients with no cardiac abnormalities (referred to as normals), 15 with DCM, and 15 with HOCM as determined by echocardiography underwent contrast-enhanced, retrospectively electrocardiography (ECG)-gated 64-slice CT of the heart. The MA was manually segmented in 1 of the RR interval with dedicated 3D software employing the point-wrap algorithm. The MA shape, area size, change of the MA area, and apicobasal MA motion throughout the cardiac cycle was determined and compared between the groups. Intercommissural distances were measured with CT and compared with findings during surgery in 9 patients undergoing ring annuloplasty. RESULTS: The MA was nonplanar in all phases and subjects, being largest in diastole and smallest in systole. The MA area was significantly (P < 0.001) larger in patients with DCM (11.5 +/- 4.1 cm/m) as compared with normals (5.5 +/- 0.9 cm/m) and HOCM (4.7 +/- 0.9 cm/m). The change of MA area throughout the cardiac cycle was significantly (P < 0.017) smaller in patients with DCM (12.2 +/- 3. HOCM (20.5 +/- 7. (P < 0.017) smaller in patients with DCM (2.2 +/- 1.0 mm/m) as compared with normals (3.6 +/- 0.8 mm/m) and HOCM (2.7 +/- 0.7 mm/m). Intercommissural distances as determined by CT showed a good correlation (r = 0.68, P < 0.05) with intraoperative measurements (mean difference, 0.44 mm; limits of agreement, -2.73-3.62 mm). CONCLUSION: Our study provides in vivo human data on the 3D shape, size, and motion of the MA in healthy subjects. Significant changes in size and motion of the MA were noted in patients with HOCM.
Publisher Lippincott Williams & Wilkins
ISSN/ISBN 0020-9996
edoc-URL http://edoc.unibas.ch/dok/A5250266
Full Text on edoc No
Digital Object Identifier DOI 10.1097/RLI.0b013e3181994a73
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/19212270
ISI-Number WOS:000264514500005
Document type (ISI) Journal Article
 
   

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