Airway epithelium-derived transforming growth factor-beta is a regulator of fibroblast proliferation in both fibrotic and normal subjects
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1195408
Author(s) Hostettler, K E; Roth, M; Burgess, J K; Gencay, M M; Gambazzi, F; Black, J L; Tamm, M; Borger, P
Author(s) at UniBasel Tamm, Michael
Year 2008
Title Airway epithelium-derived transforming growth factor-beta is a regulator of fibroblast proliferation in both fibrotic and normal subjects
Journal Clinical & experimental allergy
Volume 38
Number 8
Pages / Article-Number 1309-17
Keywords airway epithelial cell, airway remodelling, cell-cell interaction, epithelial-mesenchymal trophic unit, fibrosis, lung fibroblast, molecular mechanism
Abstract In the healthy lung, airway epithelial cells (AEC) regulate fibroblast proliferation through release of soluble factors, such as prostaglandins and proteins. Fibroproliferative diseases and airway remodelling may result from an inadequate generation of suppressive factors by AEC or the inability of fibroblasts to respond to them appropriately.
Publisher Blackwell
ISSN/ISBN 0954-7894
edoc-URL http://edoc.unibas.ch/dok/A6005591
Full Text on edoc No
Digital Object Identifier DOI 10.1111/j.1365-2222.2008.03017.x
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18503568
ISI-Number WOS:000257778300010
Document type (ISI) Journal Article
 
   

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