DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1

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DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	1195406
Author(s)	Seidel, Petra; Goulet, Stephanie; Hostettler, Katrin; Tamm, Michael; Roth, Michael
Author(s) at UniBasel	Roth-Chiarello, Michael Tamm, Michael
Year	2010
Title	DMF inhibits PDGF-BB induced airway smooth muscle cell proliferation through induction of heme-oxygenase-1
Journal	Respiratory research
Volume	11
Pages / Article-Number	145
Abstract	Airway wall remodelling is an important pathology of asthma. Growth factor induced airway smooth muscle cell (ASMC) proliferation is thought to be the major cause of airway wall thickening in asthma. Earlier we reported that Dimethylfumarate (DMF) inhibits platelet-derived growth factor (PDGF)-BB induced mitogen and stress activated kinase (MSK)-1 and CREB activity as well as IL-6 secretion by ASMC. In addition, DMF altered intracellular glutathione levels and thereby reduced proliferation of other cell types.
Publisher	BioMed Central
ISSN/ISBN	1465-9921
edoc-URL	http://edoc.unibas.ch/dok/A6005589
Full Text on edoc	No
Digital Object Identifier DOI	10.1186/1465-9921-11-145
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/20961405
ISI-Number	WOS:000283936900001
Document type (ISI)	Journal Article

03/05/2024

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