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Autoantibodies against complement C1q in acute post-streptococcal glomerulonephritis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1195334
Author(s) Kozyro, Ina; Korosteleva, Ludmila; Chernoshej, Dmitryj; Danner, Doris; Sukalo, Alexander; Trendelenburg, Marten
Author(s) at UniBasel Trendelenburg, Marten
Year 2008
Title Autoantibodies against complement C1q in acute post-streptococcal glomerulonephritis
Journal Clinical immunology
Volume 128
Number 3
Pages / Article-Number 409-14
Keywords APSGN, autoantibody, complement, glomerulonephritis
Abstract Autoantibodies against complement C1q (anti-C1q) strongly correlate with the occurrence of severe lupus nephritis. Recent data suggest that anti-C1q might also correlate with more severe forms of acute post-streptococcal glomerulonephritis (APSGN). Therefore, we prospectively investigated the role of anti-C1q in 50 children with newly diagnosed APSGN. Associations between anti-C1q and disease manifestations as well as serum complement concentrations were analyzed. Nineteen of the 50 children (38%) with APSGN were positive for anti-C1q compared to 0/40 healthy controls. Levels of anti-C1q correlated negatively with serum C1q and C3 concentrations. Anti-C1q positive patients had significantly higher proteinuria and serum creatinine as well as more often oliguria, hypertension and delayed resolution of the disease than patients without anti-C1q. The data point to a potential pathogenic role of anti-C1q in APSGN. Determination of anti-C1q might help to identify patients at risk for prolonged courses of the disease.
Publisher Elsevier
ISSN/ISBN 1090-2341
edoc-URL http://edoc.unibas.ch/dok/A6005517
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.clim.2008.04.005
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18544473
ISI-Number WOS:000258734100016
Document type (ISI) Journal Article
 
   

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