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GABAergic dysfunction in essential tremor : an 11C-flumazenil PET study
Journal
Journal of nuclear medicine
Volume
51
Number
7
Pages / Article-Number
1030-5
Keywords
tremor, GABA, flumazenil, PET
Abstract
Essential tremor is the most common movement disorder, but the underlying pathophysiology is not well understood. A primary overactivity of cerebellothalamic output pathways is the most conspicuous finding, as indicated by animal and human studies. It has been argued that this overactivity may be due to impaired central inhibition, and converging evidence points toward a potential role of gamma-aminobutyric acid (GABA) dysfunction in tremor generation.
