Assessment of muscle oxygenation with balanced SSFP: a quantitative signal analysis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 1195031
Author(s) Klarhöfer, Markus; Madörin, Philipp; Bilecen, Deniz; Scheffler, Klaus
Author(s) at UniBasel Scheffler, Klaus
Bilecen, Deniz
Year 2008
Title Assessment of muscle oxygenation with balanced SSFP: a quantitative signal analysis
Journal Journal of magnetic resonance imaging
Volume 27
Number 5
Pages / Article-Number 1169-74
Keywords muscle BOLD, balanced SSFP, tissue oxygenation, reactive hyperemia, transverse relaxation
Abstract PURPOSE: To investigate the feasibility of balanced steady-state free precession (b-SSFP) for blood oxygenation level-dependent (BOLD) MRI during a short-term ischemia/reactive hyperemia (RH) experiment on human calf muscles. MATERIALS AND METHODS: To investigate contributions to the b-SSFP signal during an RH experiment, the relaxation times T(1), T(2), and T(2) (*) were quantified in an interleaved fashion. Data from soleus, gastrocnemius, and tibialis muscle groups of five healthy subjects were evaluated. RESULTS: During ischemia a decreased b-SSFP signal amplitude as well as a decrease in T(2), T(2) (*), and the initial intensity I(0) was observed. RH provoked an overshoot of T(2), T(2) (*), and the b-SSFP signal. No paradigm-related changes in T(1) were observed. Comparing the evolution of transverse relaxation times, initial intensity, and b-SSFP signal amplitude, we concluded that the measured b-SSFP signal in muscle tissue is not only determined by T(2) variations but also significantly influenced by I(0) changes. These I(0) changes are attributed to spin density variations since inflow effects were suppressed by saturation bands. CONCLUSION: b-SSFP signal changes during a RH paradigm cannot unambiguously be assigned to oxygenation changes. Therefore, care has to be taken with their interpretation.
Publisher Williams and Wilkins
ISSN/ISBN 1053-1807
Full Text on edoc No
Digital Object Identifier DOI 10.1002/jmri.21334
PubMed ID
ISI-Number WOS:000255622700030
Document type (ISI) Journal Article

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