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Is there a regulatory role of immunoglobulins on tissue forming cells relevant in chronic inflammatory lung diseases?
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1194980
Author(s) Roth, Michael
Author(s) at UniBasel Roth-Chiarello, Michael
Year 2011
Title Is there a regulatory role of immunoglobulins on tissue forming cells relevant in chronic inflammatory lung diseases?
Journal Journal of allergy
Volume 2011
Pages / Article-Number 721517
Abstract Epithelial cells, fibroblasts and smooth muscle cells together form and give structure to the airway wall. These three tissue forming cell types are structure giving elements and participate in the immune response to inhaled particles including allergens and dust. All three cell types actively contribute to the pathogenesis of chronic inflammatory lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). Tissue forming cells respond directly to allergens through activated immunoglobulins which then bind to their corresponding cell surface receptors. It was only recently reported that allergens and particles traffic through epithelial cells without modification and bind to the immunoglobulin receptors on the surface of sub-epithelial mesenchymal cells. In consequence, these cells secrete pro-inflammatory cytokines, thereby extending the local inflammation. Furthermore, activation of the immunoglobulin receptors can induce proliferation and tissue remodeling of the tissue forming cells. New studies using anti-IgE antibody therapy indicate that the inhibition of immunoglobulins reduces the response of tissue forming cells. The unmeasured questions are: (i) why do tissue forming cells express immunoglobulin receptors and (ii) do tissue forming cells process immunoglobulin receptor bound particles? The focus of this review is to provide an overview of the expression and function of various immunoglobulin receptors.
Publisher Hindawi
ISSN/ISBN 1687-9791 (Electronic) 1687-9783 (Linking)
edoc-URL http://edoc.unibas.ch/dok/A6005174
Full Text on edoc No
Digital Object Identifier DOI 10.1155/2011/721517
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/22121383
ISI-Number MEDLINE:22121383
Document type (ISI) Journal Article
 
   

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