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B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1194827
Author(s) Maeder, M T; Brutsche, M H; Staub, D; Morgenthaler, N G; Bergmann, A; Noveanu, M; Laule, K; Breidthardt, T; Christ, A; Klima, T; Reichlin, T; Potocki, M; Mueller, C
Author(s) at UniBasel Brutsche, Martin
Reichlin, Tobias
Müller, Christian
Staub, Daniel
Year 2009
Title B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption
Journal Journal of internal medicine
Volume 265
Number 5
Pages / Article-Number 604-15
Keywords biomarker, clinical physiology, lung physiology, noninvasive assessment, physical stress
Abstract

To assess the utility of B-type natriuretic peptide (BNP) and C-terminal-pro-endothelin-1 (CT-proET-1) to predict a severely impaired peak oxygen consumption (peak VO(2), < 14 mL kg(-1) min(-1)) in patients referred for cardiopulmonary exercise testing.; Cross-sectional study.; Tertiary care center.; Peak VO(2), BNP and CT-proET-1 were assessed in 141 consecutive patients referred for cardiopulmonary exercise testing.; B-type natriuretic peptide [median (interquartile range) 48 (38-319) vs. 33 (15-86) pg mL(-1); P = 0.002] and CT-proET-1 [87 (76-95) vs. 60 (52-74) pmol L(-1); P < 0.001] were higher in patients with a peak VO(2) < 14 mL kg(-1) min(-1) (n = 30) than in those with a peak VO(2) > or = 14 mL kg(-1) min(-1) (n = 111). CT-pro-ET-1 had a higher area under the receiver-operator-characteristics curve (AUC) to predict a peak VO(2) < 14 mL kg(-1) min(-1) than BNP (0.79 vs. 0.68; P = 0.04). The optimal BNP cut-off of 37.2 pg mL(-1) had a sensitivity of 80% and a specificity of 56%. The optimal CT-proET-1 cut-off of 74.4 pmol L(-1) had a sensitivity of 80% and specificity of 76%. A five-item score composed of body mass index, diabetes, forced expiratory volume within the first second, alveolo-arterial oxygen pressure difference, and BNP had an AUC of 0.88 to predict a peak VO(2) < 14 mL kg(-1) min(-1). Adding CT-proET-1 to the score resulted in an AUC of 0.92.; C-terminal-pro-endothelin-1 is superior to BNP for the prediction of a peak VO(2) < 14 mL kg(-1) min(-1) in patients referred for CPET. A score incorporating body mass index, diabetes status, spirometry, blood gases, BNP and CT-proET-1 improves the prediction of a peak VO(2) < 14 mL kg(-1) min(-1) based on single biomarkers.

Publisher Blackwell
ISSN/ISBN 0954-6820
edoc-URL http://edoc.unibas.ch/dok/A5843864
Full Text on edoc No
Digital Object Identifier DOI 10.1111/j.1365-2796.2009.02071.x
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/19226375
ISI-Number WOS:000264959000009
Document type (ISI) Journal Article
 
   

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