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Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages
Journal
Arthritis research & therapy
Volume
12
Number
2
Pages / Article-Number
R34
Abstract
Oxygen is a critical parameter proposed to modulate the functions of chondrocytes ex-vivo as well as in damaged joints. This article investigates the effect of low (more physiological) oxygen percentage on the biosynthetic and catabolic activity of human articular chondrocytes (HAC) at different phases of in vitro culture.