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Gray matters! : mapping the transition to psychosis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1194650
Author(s) Borgwardt, Stefan; McGuire, Philip; Fusar-Poli, Paolo
Author(s) at UniBasel Borgwardt, Stefan
Year 2011
Title Gray matters! : mapping the transition to psychosis
Journal Schizophrenia research
Volume 133
Number 1-3
Pages / Article-Number 63-7
Keywords Schizophrenia, Psychosis, MRI, VBM, Gray matter, High-risk
Mesh terms Brain, pathology; Brain Mapping; Cross-Sectional Studies; Humans; Longitudinal Studies; Neuroimaging; Psychotic Disorders, pathology; PubMed, statistics & numerical data
Abstract Despite many neuroimaging studies on schizophrenia showing brain abnormalities the exact time course of their occurrence is unknown. Studies of gray matter are a powerful tool in biological psychiatry and provide an unprecedented opportunity for brain structure investigations. Here we compared cross-sectional and longitudinal structural neuroimaging studies distinguishing high-risk subjects developing psychosis from those who did not. These investigations on gray matter volumes in the prodromal phase potentially identify core structural markers of impending psychoses and clarify dynamic changes underlying the transition. Subjects at high risk of psychosis show qualitatively similar albeit less severe gray matter abnormalities as patients with psychosis.
Publisher Elsevier
ISSN/ISBN 0920-9964
edoc-URL http://edoc.unibas.ch/dok/A6004857
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.schres.2011.08.021
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21943556
ISI-Number WOS:000298512500011
Document type (ISI) Journal Article, Review
 
   

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