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Allogeneic hematopoietic stem cell transplantation for severe autoimmune diseases
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1194272
Author(s) Gratwohl, Alois
Author(s) at UniBasel Gratwohl, Alois A.
Year 2008
Title Allogeneic hematopoietic stem cell transplantation for severe autoimmune diseases
Journal Autoimmunity
Volume 41
Number 8
Pages / Article-Number 673-8
Mesh terms Adolescent; Adult; Autoimmune Diseases, therapy; Child; Child, Preschool; Female; Graft vs Host Disease, immunology; Guidelines as Topic; Hematopoietic Stem Cell Transplantation, standards; Humans; Infant; Male; Middle Aged; Young Adult
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) offers the unique opportunity to replace a diseased hematopoietic or immune system by healthy donor cells. Proof of principle comes from experimental animal data, from the experience with severe aplastic anemia, from observations of patients with concomitant autoimmune disease and from scattered case reports. Complete remissions have been described as well as failures. Allogeneic HSCT remains associated with significant morbidity and mortality. The potential risks might outweight the benefits. Currently, allogeneic HSCT cannot be recommended in general. Carefully conducted prospective studies are warranted to define target populations and best technology to be used. Conditions for such studies have been identified by an international expert panel.
Publisher Taylor & Francis
ISSN/ISBN 0891-6934 ; 1607-842X
edoc-URL https://edoc.unibas.ch/63223/
Full Text on edoc No
Digital Object Identifier DOI 10.1080/08916930802197677
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18958760
ISI-Number WOS:000262134200019
Document type (ISI) Journal Article
 
   

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