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Synergistic effects of elevated systolic blood pressure and hypercholesterolemia on carotid intima-media thickness in children and adolescents
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1194137
Author(s) Krebs, Andreas; Schmidt-Trucksäss, Arno; Alt, Janine; Doerfer, Jürgen; Krebs, Kristin; Winkler, Karl; Schwab, Karl Otfried
Author(s) at UniBasel Schmidt-Trucksäss, Arno
Year 2009
Title Synergistic effects of elevated systolic blood pressure and hypercholesterolemia on carotid intima-media thickness in children and adolescents
Journal Pediatric cardiology
Volume 30
Number 8
Pages / Article-Number 1131-6
Keywords Carotid intima-media thickness, Hypercholesterolemia, Systolic blood pressure
Abstract This study aimed to investigate the synergistic effects of elevated systolic blood pressure (SBP) and hypercholesterolemia on carotid intima-media thickness (cIMT). For this study, 60 children with hypercholesterolemia and 40 healthy control children were divided into four subgroups: hypercholesterolemic children with normal (<90th percentile) or elevated (>or= 90th percentile) SBP and control children with normal or elevated SBP. The highest mean and maximal cIMT values were found in the hypercholesterolemic children with elevated SBP and were significantly different from those of all the other groups. The synergistic effects of elevated SBP and hypercholesterolemia lead to a significant increase in cIMT as a subclinical sign of early atherosclerosis.
Publisher Springer-Verlag
ISSN/ISBN 0172-0643
edoc-URL http://edoc.unibas.ch/dok/A6004365
Full Text on edoc No
Digital Object Identifier DOI 10.1007/s00246-009-9510-6
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/19768489
ISI-Number WOS:000271028500012
Document type (ISI) Article
 
   

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