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Loss of VHL and hypoxia provokes PAX2 up-regulation in clear cell renal cell carcinoma
Journal
Clinical cancer research : a journal of clinical and translational research
Volume
15
Number
10
Pages / Article-Number
3297-304
Abstract
The paired box gene 2, PAX2, encodes for a transcription factor that is up-regulated during nephrogenesis and becomes silenced in mature epithelium of the glomeruli, the proximal, and distal tubules. Reactivation of PAX2 has been frequently observed in clear cell renal cell carcinoma (ccRCC), a tumor type characterized by loss of von Hippel-Lindau (VHL) tumor suppressor function. The regulation of PAX2 expression in ccRCC is unknown.
