Artemether and tribendimidine lack activity in experimental treatment of Paragonimus westermani in the dog
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1194006
Author(s) Xue, Jian; Utzinger, Jürg; Zhang, Yong-Nian; Tanner, Marcel; Keiser, Jennifer; Xiao, Shu-Hua
Author(s) at UniBasel Keiser, Jennifer
Year 2008
Title Artemether and tribendimidine lack activity in experimental treatment of Paragonimus westermani in the dog
Journal Parasitology research
Volume 102
Number 3
Pages / Article-Number 537-40
Keywords artemether, tribendimidine, food-borne trematodiasis, Paragonimus westermani, in vivo study, dog
Abstract Artemether and tribendimidine are active against several trematode species, but no data are available regarding the lung fluke Paragonimus westermani. We infected six dogs with 100 P. westermani metacercariae each. At day 103 post-infection, four dogs were treated orally for 3 days with either artemether (total dose, 66.7 and 75 mg/kg) or tribendimidine (total dose, 100 mg/kg). The remaining dogs were left untreated and served as control. Sixteen days after the final dosing, dogs were killed, and P. westermani flukes were recovered from the lungs and counted. Neither artemether nor tribendimidine showed activity against P. westermani at this dose regimen in dogs.
Publisher Springer-Verlag
ISSN/ISBN 0932-0113
edoc-URL http://edoc.unibas.ch/dok/A6004239
Full Text on edoc No
Digital Object Identifier DOI 10.1007/s00436-007-0801-7
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18066711
ISI-Number WOS:000252675800027
Document type (ISI) Journal Article
 
   

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