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Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension : prospective cohort study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1193788
Author(s) Conen, David; Glynn, Robert J; Buring, Julie E; Ridker, Paul M; Zee, Robert Y L
Author(s) at UniBasel Conen, David
Year 2008
Title Association of renin-angiotensin and endothelial nitric oxide synthase gene polymorphisms with blood pressure progression and incident hypertension : prospective cohort study
Journal Journal of Hypertension
Volume 26
Number 9
Pages / Article-Number 1780-6
Keywords angiotensin-converting enzyme, blood pressure, gene polymorphism, hypertension, nitric oxide synthase, renin-angiotensin system
Abstract OBJECTIVE: The renin-angiotensin system and endothelial function have both been associated with hypertension. The aim of the present study was to assess the relationship of six previously characterized gene variants in the renin-angiotensin system and the NOS3 gene with blood pressure progression and incident hypertension. METHODS: We analyzed data from 18 436 Caucasian women who participated in a prospective cohort study and were free of hypertension at baseline. Six previously characterized single nucleotide polymorphisms (NOS3 rs1800779, NOS3 rs3918226, NOS3 rs1799983, ACE rs1799752, AGT rs699, and AGTR1 rs5186) were genotyped. Blood pressure progression at 48 months and incident hypertension during the entire follow-up according to the different genotypes and inferred haplotypes were assessed by logistic regression and Cox proportional hazards models, respectively. RESULTS: At 48 months, 47.4% of the women had blood pressure progression. The odds ratios (95% confidence intervals) for blood pressure progression associated with NOS3 rs1800779, NOS3 rs3918226, NOS3 rs1799983, ACE rs1799752, AGT rs699, and AGTR1 rs5186 were 1.00 (0.96-1.05), 1.00 (0.92-1.09), 0.99 (0.94-1.04), 0.96 (0.92-1.01), 1.04 (0.99-1.08), and 1.03 (0.98-1.08), respectively. During 9.8 years of follow-up, 29.6% of women developed incident hypertension. The hazard ratios (95% confidence interval) for the six polymorphisms were 1.01 (0.97-1.06), 1.06 (0.99-1.14), 1.05 (1.01-1.09), 0.99 (0.95-1.02), 1.01 (0.97-1.05), and 0.99 (0.95-1.04). NOS3 haplotypes were not significantly associated with blood pressure progression (P = 0.91) or incident hypertension (P = 0.10). CONCLUSION: Blood pressure progression and incident hypertension are not consistently associated with six well-characterized genetic polymorphisms of the renin-angiotensin system and the NOS3 gene in a large cohort of Caucasian women.
Publisher Lippincott Williams & Wilkins
ISSN/ISBN 0263-6352
edoc-URL http://edoc.unibas.ch/dok/A6004027
Full Text on edoc No
Digital Object Identifier DOI 10.1097/HJH.0b013e3283077eef
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18698212
ISI-Number WOS:000259304900011
Document type (ISI) Journal Article, Randomized Controlled Trial
 
   

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