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Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1193781
Author(s) Mehling, Matthias; Hilbert, Patricia; Fritz, Stefanie; Durovic, Bojana; Eichin, Dominik; Gasser, Olivier; Kuhle, Jens; Klimkait, Thomas; Lindberg, Raija L P; Kappos, Ludwig; Hess, Christoph
Author(s) at UniBasel Klimkait, Thomas
Hess, Christoph
Lindberg Gasser, Raija L.P.
Kappos, Ludwig
Mehling, Matthias
Year 2011
Title Antigen-specific adaptive immune responses in fingolimod-treated multiple sclerosis patients
Journal Annals of neurology
Volume 69
Number 2
Pages / Article-Number 408-13
Keywords memory t-cells; oral fingolimod; virus-infection; b-cells; fty720; therapy; counts; egress
Abstract T cells exit secondary lymphoid organs along a sphingosine1-phosphate (S1P) gradient and, accordingly, are reduced in blood upon fingolimod-mediated S1P-receptor (S1PR)-blockade. Serving as a model of adaptive immunity, we characterized cellular and humoral immune responses to influenza vaccine in fingolimod-treated patients with multiple sclerosis (MS) and in untreated healthy controls. Although the mode of action of fingolimod might predict reduced immunity, vaccine-triggered T cells accumulated normally in blood despite efficient Si PR-blockade. Concentrations of anti-influenza A/B immunoglobulin (Ig)M and IgG also increased similarly in both groups. These results indicate that fingolimod-treated individuals can mount vaccine-specific adaptive immune responses comparable to healthy controls. ANN NEUROL 2011;69:408-413
Publisher Wiley-Liss
ISSN/ISBN 0364-5134
URL ://000288284900023
edoc-URL http://edoc.unibas.ch/dok/A6004020
Full Text on edoc No
Digital Object Identifier DOI 10.1002/ana.22352
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21387383
ISI-Number WOS:000288284900023
Document type (ISI) Clinical Trial, Journal Article
 
   

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