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A Randomized, Double-Blind, Placebo-Controlled Study of Light Therapy for Antepartum Depression
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1193771
Author(s) Wirz-Justice, Anna; Bader, Anja; Frisch, Ulrike; Stieglitz, Rolf-Dieter; Alder, Judith; Bitzer, Johannes; Hoesli, Irene; Jazbec, Sandra; Benedetti, Francesco; Terman, Michael; Wisner, Katherine L.; Riecher-Roessler, Anita
Author(s) at UniBasel Hösli-Krais, Irene M.
Riecher-Rössler, Anita
Bitzer, Johannes
Stieglitz, Rolf Dieter
Year 2011
Title A Randomized, Double-Blind, Placebo-Controlled Study of Light Therapy for Antepartum Depression
Journal Journal of clinical psychiatry
Volume 72
Number 7
Pages / Article-Number 986-993
Abstract Objective: Affective disorder during pregnancy is a common condition requiring careful judgment to treat the depression while minimizing risk to the fetus. Following up on promising pilot trials, we studied the efficacy of light therapy. Method: Twenty-seven pregnant women with nonseasonal major depressive disorder according to DSM-IV (outpatients, university polyclinic) were randomly assigned to 7,000 lux fluorescent bright white or 70 lux dim red (placebo) light administered at home in the morning upon awakening for 1 h/d in a 5-week double-blind trial carried out between October 2004 and October 2008. Clinical state was monitored weekly with the 29-item Structured Interview Guide for the Hamilton Depression Rating Scale (HDRS) with Atypical Depression Supplement (SIGH-ADS). Changes of rating scale scores over time were analyzed with the general linear model. Differences from baseline of SIGH-ADS and 17-item HDRS scores at every time point were the dependent variables, time was the within-subjects factor, and treatment was the between-subjects factor. The model also included baseline score of depression and gestational age at intervention start. Results: The superiority of bright light over dim light placebo was shown for both SIGH-ADS (R-2 = 0.251; F-3,F-23 = 3.91; P < .05) and HDRS (R-2 = 0.338; F-3,F-23 = 5.42; P < .01) when analyzing the week-by-week change from baseline, and HDRS scores showed a significant interaction of treatment with time (F-4,F-92 = 2.91; P < .05). Categorical analysis revealed that the response rate (HDRS >= 50% improvement) at week 5 was significantly greater for bright light (81.3%, n = 16) than for placebo light (45.5%, n = 11) (P < .05). Remission (final score 8) was attained by 68.6% versus 36.4%, respectively (P < .05). Expectation ratings did not differ significantly between groups. Conclusions: Bright white light treatment for 5 weeks improved depression during pregnancy significantly more than placebo dim red light. The study provides evidence that light therapy, a simple, cost-effective antidepressant modality with minimal side effects for the mother and no known risk for the unborn child, may be a useful non-pharmacologic approach in this difficult situation.
Publisher Physicians Postgraduate
ISSN/ISBN 0160-6689 ; 1555-2101
edoc-URL http://edoc.unibas.ch/dok/A5844254
Full Text on edoc Restricted
Digital Object Identifier DOI 10.4088/JCP.10m06188blu
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21535997
ISI-Number 000293678600016
Document type (ISI) Article
 
   

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