Logo der Universität Basel

Research Database / FORSCHUNGSDATENBANK 
PRINTDOC
 
Publication 1193698 | Verified
 

Data Entry: Please note that the research database will be replaced by UNIverse by the end of October 2023. Please enter your data into the system https://universe-intern.unibas.ch. Thanks

Login for users with Unibas email account...

Login for registered users without Unibas email account...

 
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1193698
Author(s) Dumortier, Alexis; Durham, André-Dante; Di Piazza, Matteo; Vauclair, Sophie; Koch, Ute; Ferrand, Gisèle; Ferrero, Isabel; Demehri, Shadmehr; Song, Lynda Li; Farr, Andrew G.; Leonard, Warren J.; Kopan, Raphael; Miele, Lucio; Hohl, Daniel; Finke, Daniela; Radtke, Freddy
Author(s) at UniBasel Finke, Daniela
Year 2010
Title Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin
Journal PLoS ONE
Volume 5
Number 2
Pages / Article-Number e9258
Mesh terms Animals; Cytokines, metabolism; Dermatitis, Atopic, physiopathology; Flow Cytometry; Granulocyte Colony-Stimulating Factor, metabolism; Humans; Immunoglobulins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Transgenic; Models, Biological; Myeloproliferative Disorders, physiopathology; Receptor, Notch1, physiology; Receptor, Notch2, physiology; Receptors, Cytokine, metabolism; Receptors, Notch, physiology; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction, physiology; Skin, physiopathology; Survival Analysis; Survival Rate
Abstract The Notch pathway is essential for proper epidermal differentiation during embryonic skin development. Moreover, skin specific loss of Notch signaling in the embryo results in skin barrier defects accompanied by a B-lymphoproliferative disease. However, much less is known about the consequences of loss of Notch signaling after birth.
Publisher Public Library of Science
ISSN/ISBN 1932-6203
edoc-URL http://edoc.unibas.ch/dok/A6003937
Full Text on edoc No
Digital Object Identifier DOI 10.1371/journal.pone.0009258
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20174635
ISI-Number WOS:000274654700010
Document type (ISI) Journal Article
 
   

MCSS v5.8 PRO. 0.350 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
24/04/2024