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Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD : results from the SAPALDIA cohort study 2
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
1193672
Author(s)
Bridevaux, P.-O.; Gerbase, M. W.; Schindler, C.; Dietrich, D. Felber; Curjuric, I.; Dratva, J.; Ackermann-Liebrich, U.; Probst-Hensch, N. M.; Gaspoz, J.-M.; Rochat, T.
Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD : results from the SAPALDIA cohort study 2
Journal
The European respiratory journal
Volume
34
Number
2
Pages / Article-Number
332-9
Keywords
Chronic obstructive pulmonary disease, forced expiratory volume in 1 s decline, obesity, sex differences, systemic inflammation
Abstract
Systemic inflammation may mediate the association between chronic obstructive pulmonary disease (COPD) and extrapulmonary comorbidities. We measured high-sensitivity C-reactive protein (hs-CRP) in COPD and quantified the effect modification by body weight change and sex. Using data from the Swiss study on Air Pollution and Lung Diseases in Adults (SAPALDIA; n = 5,479) with measurements of forced expiratory volume in 1 s (FEV(1)), body weight and hs-CRP, we examined the association of hs-CRP and categories of body weight change (lost weight and weight gained 0-5%, 5-9%, 9-14% and <14%) with fast FEV(1) decline. hs-CRP was elevated both in association with fast FEV(1) decline and body weight gain. Subjects with fast FEV(1) decline and weight gain (<14%) had higher hs-CRP (2.0 mg L(-1) for females versus 1.6 mg L(-1) for males). After adjustment for age, smoking, physical activity, hormonal therapy and diabetes, elevated hs-CRP (<3 mg) was found to be more likely in subjects with fast FEV(1) decline (OR(males) 1.38, OR(females) 1.42) and in those with weight gain <14% (OR(males) 2.04, OR(females) 4.51). The association of weight gain and fast FEV(1) decline predicts a higher level of systemic inflammation. Since the effect of weight gain on systemic inflammation is larger in females than in males, weight gain may be a risk factor for extrapulmonary comorbidities in females with COPD.
