Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper

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Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper

JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)

ID	1193666
Author(s)	Palmer, Ed; Naeher, Dieter
Author(s) at UniBasel	Palmer, Ed
Year	2009
Title	Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper
Journal	Nature reviews. Immunology
Volume	9
Number	3
Pages / Article-Number	207-13
Abstract	The affinity of the T-cell receptor (TCR) for self antigen is the basis for the selection of a useful (MHC-restricted) and safe (self-tolerant) T-cell repertoire. However, it has been difficult to understand how thymocytes measure ligand affinity and translate this signal into a cellular response. In this Opinion article, we propose a new model that describes how the TCR discriminates between low- and high-affinity ligands, which is based on the duration of TCR-ligand interactions and a 'zipper' mechanism that mediates the interaction of the TCR and co-receptor molecules to initiate negative-selection signalling.
Publisher	Nature Publishing Group
ISSN/ISBN	1474-1733
edoc-URL	http://edoc.unibas.ch/dok/A6003905
Full Text on edoc	No
Digital Object Identifier DOI	10.1038/nri2469
PubMed ID	http://www.ncbi.nlm.nih.gov/pubmed/19151748
ISI-Number	WOS:000263677400015
Document type (ISI)	Journal Article

16/04/2024

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