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Increased adherence after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation : a pre-experimental study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID
1193569
Author(s)
Doesch, A O; Mueller, S; Konstandin, M; Celik, S; Erbel, C; Kristen, A; Frankenstein, L; Koch, A; Dengler, T J; Ehlermann, P; Zugck, C; De Geest, S; Katus, H A
Increased adherence after switch from twice daily calcineurin inhibitor based treatment to once daily modified released tacrolimus in heart transplantation : a pre-experimental study
Journal
Transplantation proceedings
Volume
42
Number
10
Pages / Article-Number
4238-42
Abstract
Modified release tacrolimus (TAC) is a new, once-daily oral formulation of the established immunosuppressive agent TAC. Simplification of regimen has been associated with better adherence. This study evaluated patient adherence, as well as safety and efficacy among chronic stable heart transplantation (HT) patients switched from a conventional twice daily calcineurin inhibitor-based regimen (TAC or cyclosporine A [CsA]) to (once daily) modified release TAC.
