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Anti-factor IXa Aptamer reduces propagation of thrombin generation in plasma anticoagulated with warfarin
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1193499
Author(s) Szlam, Fania; Luan, Deyan; Bolliger, Daniel; Szlam, Arthur D.; Levy, Jerrold H.; Varner, Jeffrey D.; Tanaka, Kenichi A.
Author(s) at UniBasel Bolliger, Daniel
Year 2010
Title Anti-factor IXa Aptamer reduces propagation of thrombin generation in plasma anticoagulated with warfarin
Journal Thrombosis Research
Volume 125
Number 5
Pages / Article-Number 432-7
Mesh terms Anticoagulants, administration & dosage; Aptamers, Nucleotide, administration & dosage; Dose-Response Relationship, Drug; Drug Combinations; Factor IXa, antagonists & inhibitors; Humans; Plasma, metabolism; Thrombin, metabolism; Warfarin, administration & dosage
Abstract Warfarin is routinely used in the prevention and treatment of prothrombotic events. During initiation of warfarin therapy levels of factor (F) VII and protein C decrease rapidly but prothrombin, FIX and FX decline much slower. Therefore, propagation of thrombin generation (TG) remains unaffected much longer, increasing the risk of inadequate anticoagulation. Recently, a novel agent, anti-IXa aptamer, RB006, has been developed. Therefore, we have evaluated the in vitro effects of this agent in warfarin plasma.
Publisher Pergamon Press
ISSN/ISBN 0049-3848
edoc-URL https://edoc.unibas.ch/63124/
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.thromres.2009.11.018
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20004955
ISI-Number WOS:000277209200012
Document type (ISI) Journal Article
 
   

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