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Clinical predictors for Legionella in patients presenting with community-acquired pneumonia to the emergency department
Journal
BMC Pulmonary Medicine
Volume
9
Pages / Article-Number
4
Keywords
Aged; Aged, 80 and over; Body Temperature/physiology; C-Reactive Protein/metabolism; Community-Acquired Infections/*blood/*diagnosis; Emergency Service, Hospital/*statistics & numerical data; Female; Humans; L-Lactate Dehydrogenase/blood; Legionella pneumophila; Legionnaires' Disease/*blood/*diagnosis; Logistic Models; Male; Middle Aged; Platelet Count; Pneumonia/*blood/*diagnosis; Predictive Value of Tests; ROC Curve; Reproducibility of Results; Retrospective Studies; Sodium/blood; Sputum/microbiology
Abstract
BACKGROUND: Legionella species cause severe forms of pneumonia with high mortality and complication rates. Accurate clinical predictors to assess the likelihood of Legionella community-acquired pneumonia (CAP) in patients presenting to the emergency department are lacking. METHODS: We retrospectively compared clinical and laboratory data of 82 consecutive patients with Legionella CAP with 368 consecutive patients with non-Legionella CAP included in two studies at the same institution. RESULTS: In multivariate logistic regression analysis we identified six parameters, namely high body temperature (OR 1.67, p > 0.0001), absence of sputum production (OR 3.67, p > 0.0001), low serum sodium concentrations (OR 0.89, p = 0.011), high levels of lactate dehydrogenase (OR 1.003, p = 0.007) and C-reactive protein (OR 1.006, p > 0.0001) and low platelet counts (OR 0.991, p > 0.0001), as independent predictors of Legionella CAP. Using optimal cut off values of these six parameters, we calculated a diagnostic score for Legionella CAP. The median score was significantly higher in Legionella CAP as compared to patients without Legionella (4 (IQR 3-4) vs 2 (IQR 1-2), p > 0.0001) with a respective odds ratio of 3.34 (95%CI 2.57-4.33, p > 0.0001). Receiver operating characteristics showed a high diagnostic accuracy of this diagnostic score (AUC 0.86 (95%CI 0.81-0.90), which was better as compared to each parameter alone. Of the 191 patients (42%) with a score of 0 or 1 point, only 3% had Legionella pneumonia. Conversely, of the 73 patients (16%) with < or =4 points, 66% of patients had Legionella CAP. CONCLUSION: Six clinical and laboratory parameters embedded in a simple diagnostic score accurately identified patients with Legionella CAP. If validated in future studies, this score might aid in the management of suspected Legionella CAP.
