Immunomodulatory effects of aerobic training in obesity
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 1193232
Author(s) Nickel, Thomas; Hanssen, Henner; Emslander, Ingrid; Drexel, Verena; Hertel, Gernot; Schmidt-Trucksäss, Arno; Summo, Claudia; Sisic, Zeljka; Lambert, Marius; Hoster, Eva; Halle, Martin; Weis, Michael
Author(s) at UniBasel Schmidt-Trucksäss, Arno
Hanssen, Henner
Year 2011
Title Immunomodulatory effects of aerobic training in obesity
Journal Mediators of inflammation
Volume 2011
Pages / Article-Number 308965
Mesh terms Adiponectin, blood; Adult; Antigens, CD1; Antigens, Surface, metabolism; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Exercise, physiology; Flow Cytometry; Glycoproteins; Humans; Interleukin-6, blood; Lectins, C-Type, metabolism; Lipoproteins, LDL, blood; Male; Membrane Glycoproteins, metabolism; Middle Aged; Myeloid Differentiation Factor 88; Obesity, therapy; Receptors, Immunologic, metabolism; Reverse Transcriptase Polymerase Chain Reaction; Toll-Like Receptor 2, genetics; Toll-Like Receptor 4, genetics; Toll-Like Receptor 7, genetics; Tumor Necrosis Factor-alpha, blood
Abstract Physical inactivity and obesity are independent risk factors for atherosclerosis. We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes. Markers of the innate immune response were investigated in obese (ONE: ET≤40 km/week) and lean athletes (LNE: ET≤40 km/week and LE: ET≥55 km/week).; Circulating dendritic cells (DC) were analyzed by flow-cytometry for BDCA-1/-2-expression. TLR-2/-4/-7 and MyD88 were analyzed by RT-PCR and Western blot. Circulating oxLDL levels were analyzed by ELISA.; BDCA-1 expression at baseline was lower in ONE compared to both other groups (ONE 0.15%; LNE 0.27%; LE 0.33%; P < .05), but significantly increased in ONE after training (+50%; P < .05). In contrast, BDCA-2 expression at baseline was higher in ONE (ONE 0.25%; LNE 0.11%; LE 0.09%; P < .05) and decreased in ONE after the 10-week training period (-27%; P < .05). Gene activations of TLR-4 and TLR-7 with corresponding protein increase were found for all three groups (P < .01/P < .05) compared to pre training. A reduction of oxLDL levels was seen in ONE (-61%; P < .05).; Intensified exercise induces an increase of BDCA-1+ DCs and TLR-4/-7 in obese athletes. We hereby describe new immune modulatory effects, which-through regular aerobic exercise-modulate innate immunity and pro-inflammatory cytokines in obesity.
Publisher Hindawi
ISSN/ISBN 0962-9351 ; 1466-1861
Full Text on edoc No
Digital Object Identifier DOI 10.1155/2011/308965
PubMed ID
ISI-Number WOS:000290344200001
Document type (ISI) Journal Article

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