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A patient with SLE-associated thrombotic microangiopathy and non-neutralizing antibodies against ADAMTS13.
Journal
Nephrology, dialysis, transplantation
Volume
25
Number
5
Pages / Article-Number
1720-2
Keywords
ADAMTS13, autoantibodies, SLE, TTP
Abstract
In this case report, we describe for the first time a patient with thrombotic thrombocytopaenic purpura (TTP) accompanying highly active systemic lupus erythematosus (SLE) that was associated with non-neutralizing antibodies against the plasma metalloprotease ADAMTS13. Those non-neutralizing antibodies could have been the cause of ADAMTS13 depletion and consecutive TTP. More extensive analyses are required to determine the prevalence as well as the clinical relevance of non-neutralizing antibodies against ADAMTS13 in SLE patients.
