Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1192948
Author(s) Keiser, Jennifer; Vargas, Mireille; Doenhoff, Michael J
Author(s) at UniBasel Keiser, Jennifer
Year 2010
Title Activity of artemether and mefloquine against juvenile and adult Schistosoma mansoni in athymic and immunocompetent NMRI mice
Journal American Journal of Tropical Medicine and Hygiene
Volume 82
Number 1
Pages / Article-Number 112-4
Abstract Immune effector mechanisms can enhance the activity of antischistosomal drugs. We examined the in vivo effect of single oral doses of the antimalarials artemether (400 mg/kg) and mefloquine (200 mg/kg), recently described to have promising antischistosomal properties, against juvenile and adult Schistosoma mansoni in T cell-deficient and in comparably infected age- and sex-matched immunologically intact control mice. Artemether and mefloquine are equally effective in athymic and immunocompetent mice. Artemether treatment resulted in total and female worm burden reductions ranging between 71.1% and 85.3%, whereas mefloquine achieved total and female worm burden reductions of 80.4-97.8%. In conclusion, artemether and mefloquine act T-cell independently and no synergistic interaction with the immune response was involved
Publisher Williams and Wilkins
ISSN/ISBN 0002-9637
edoc-URL http://edoc.unibas.ch/dok/A5842797
Full Text on edoc No
Digital Object Identifier DOI 10.4269/ajtmh.2010.09-0461
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20065004
ISI-Number WOS:000273367400020
Document type (ISI) Journal Article
 
   

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