A single dose of Sildenafil does not enhance FeNO : a randomised, cross-over and placebo-controlled study
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1192904
Author(s) Rothe, Thomas; Karrer, Werner; Schindler, Christian
Author(s) at UniBasel Schindler, Christian
Year 2010
Title A single dose of Sildenafil does not enhance FeNO : a randomised, cross-over and placebo-controlled study
Journal Respiratory medicine
Volume 104
Number 6
Pages / Article-Number 788-93
Keywords Asthma, Asthma control, Exhaled nitric oxide, Sildenafil
Abstract

Monitoring of asthma control can be performed with different means including measurement of the concentration of nitric oxide (NO) in exhaled air. Due to its action on the NO-metabolism; we hypothesized that the intake of Sildenafil might augment and falsify the NO-values in exhaled air of subjects taking the drug to treat erectile dysfunction. This randomised, placebo-controlled cross-over study including 10 male non-asthmatic volunteers taking a single dose of 50 mg Sildenafil did not confirm this assumption in non-asthmatic subjects. We cannot think of any reason why asthmatics should behave differently. On the basis of these results, it does not seem necessary to ask asthma patients with elevated NO-values if they had taken any selective inhibitor of the cGMP-specific phosphodiesterase Type 5 as Sildenafil prior to the test

Publisher Saunders
ISSN/ISBN 0954-6111
edoc-URL http://edoc.unibas.ch/dok/A5842791
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.rmed.2009.12.011
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20079617
ISI-Number WOS:000278692500004
Document type (ISI) Journal Article, Randomized Controlled Trial
 
   

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