Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1192813
Author(s) Khoury, Maroun; Courties, Gabriel; Fabre, Sylvie; Bouffi, Carine; Seemayer, Christian A; Vervoordeldonk, Margriet J; Tak, Paul P; Jorgensen, Christian; Apparailly, Florence
Author(s) at UniBasel Seemayer, Christian A.
Year 2010
Title Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis
Journal Arthritis & rheumatism
Volume 62
Number 3
Pages / Article-Number 765-70
Abstract RNA interference (RNAi) is a powerful tool for sequence-specific gene silencing, and interest in its application in human diseases is growing. Given the success of recent strategies for administering gene therapy in rheumatoid arthritis using recombinant vectors such as adeno-associated virus type 5 (rAAV5) for optimized intraarticular gene transfer, we undertook the present study to determine the feasibility of using rAAV5-mediated RNAi-based therapy in arthritis.
Publisher Wiley-Liss
ISSN/ISBN 0004-3591
edoc-URL http://edoc.unibas.ch/dok/A6003061
Full Text on edoc No
Digital Object Identifier DOI 10.1002/art.27302
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20187132
ISI-Number WOS:000279432200016
Document type (ISI) Journal Article
 
   

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