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Aberrations of the MYC gene in unselected cases of diffuse large B-cell lymphoma are rare and unpredictable by morphological or immunohistochemical assessment
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1192772
Author(s) Obermann, E C; Csato, M; Dirnhofer, S; Tzankov, A
Author(s) at UniBasel Tzankov, Alexandar
Dirnhofer, Stephan
Year 2009
Title Aberrations of the MYC gene in unselected cases of diffuse large B-cell lymphoma are rare and unpredictable by morphological or immunohistochemical assessment
Journal Journal of clinical pathology : the journal of the Association of Clinical Pathologists
Volume 62
Number 8
Pages / Article-Number 754-6
Abstract Diffuse large B-cell lymphomas (DLBCL) with aberrations of MYC probably represent a distinct clinicopathological entity following an aggressive course. Their incidence in unselected DLBCL collectives is debatable and the identification of such cases may be difficult. Therefore, the molecular epidemiology of MYC aberrations in DLBCL and whether they can be predicted by morphology and immunohistochemistry were studied on tissue microarrays containing 333 cases. Evaluation of MYC by fluorescence in situ hybridisation was successful in 220/333 (66%) cases. 9/220 (4%) cases showed MYC breaks. Re-evaluation of these tumours did not show any specific morphological and/or immunohistochemical features. The median survival time was 9 months for the respective patients, as opposed to 80 for patients without MYC breaks. The presence of MYC breaks in DLBCL cannot be reliably predicted by conventional methods. Since such patients might profit from different forms of treatment, routine testing of all DLBCL for MYC aberrations is suggested.
Publisher British Medical Association
ISSN/ISBN 0021-9746
edoc-URL http://edoc.unibas.ch/dok/A6003020
Full Text on edoc No
Digital Object Identifier DOI 10.1136/jcp.2009.065227
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/19638549
ISI-Number WOS:000268399100018
Document type (ISI) Journal Article
 
   

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