A PKC-dependent recruitment of MMP-2 controls semaphorin-3A growth-promoting effect in cortical dendrites
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1192756
Author(s) Gonthier, Bertrand; Koncina, Eric; Satkauskas, Saulius; Perraut, Martine; Roussel, Guy; Aunis, Dominique; Kapfhammer, Josef P.; Bagnard, Dominique
Author(s) at UniBasel Kapfhammer, Josef
Year 2009
Title A PKC-dependent recruitment of MMP-2 controls semaphorin-3A growth-promoting effect in cortical dendrites
Journal PLoS ONE
Volume 4
Number 4
Abstract There is increasing evidence for a crucial role of proteases and metalloproteinases during axon growth and guidance. In this context, we recently described a functional link between the chemoattractive Sema3C and Matrix metalloproteinase 3 (MMP3). Here, we provide data demonstrating the involvement of MMP-2 to trigger the growth-promoting effect of Sema3A in cortical dendrites. The in situ analysis of MMP-2 expression and activity is consistent with a functional growth assay demonstrating in vitro that the pharmacological inhibition of MMP-2 reduces the growth of cortical dendrites in response to Sema3A. Hence, our results suggest that the selective recruitment and activation of MMP-2 in response to Sema3A requires a PKC alpha dependent mechanism. Altogether, we provide a second set of data supporting MMPs as effectors of the growth-promoting effects of semaphorins, and we identify the potential signalling pathway involved.
Publisher Public Library of Science
ISSN/ISBN 1932-6203
edoc-URL http://edoc.unibas.ch/dok/A5262184
Full Text on edoc No
Digital Object Identifier DOI 10.1371/journal.pone.0005099
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/19352510
ISI-Number WOS:000265505700010
Document type (ISI) Article
 
   

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