A highly sensitive electrochemiluminescence immunoassay for the neurofilament heavy chain protein
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1192678
Author(s) Kuhle, Jens; Regeniter, Axel; Leppert, David; Mehling, Matthias; Kappos, Ludwig; Lindberg, Raija L P; Petzold, Axel
Author(s) at UniBasel Lindberg Gasser, Raija L.P.
Kappos, Ludwig
Year 2010
Title A highly sensitive electrochemiluminescence immunoassay for the neurofilament heavy chain protein
Journal Journal of neuroimmunology
Volume 220
Number 1-2
Pages / Article-Number 114-9
Keywords Neurofilament heavy chain (NfH), Electrochemiluminescence (ECL), Multiple sclerosis, Amyotrophic lateral sclerosis, Guillain Barre syndrome, Mild cognitive impairment/Alzheimer's disease
Abstract The loss of neurological function is closely related to axonal damage. Neurofilament subunits are concentrated in neurons and axons and have emerged as promising biomarkers for neurodegeneration. Electrochemiluminescence (ECL) based assays are known to be of superior sensitivity and require less sample volume than conventional ELISAs.
Publisher Elsevier
ISSN/ISBN 0165-5728
edoc-URL http://edoc.unibas.ch/dok/A6002928
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.jneuroim.2010.01.004
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/20117845
ISI-Number WOS:000276469900015
Document type (ISI) Journal Article
 
   

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