Aqueous oxidation of alcohols catalyzed by artificial metalloenzymes based on the biotin-avidin technology
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 116770
Author(s) Thomas, Christophe M.; Letondor, Christophe; Humbert, Nicolas; Ward, Thomas R.
Author(s) at UniBasel Ward, Thomas R.
Year 2005
Title Aqueous oxidation of alcohols catalyzed by artificial metalloenzymes based on the biotin-avidin technology
Journal Journal of Organometallic Chemistry
Volume 690
Number 20
Pages / Article-Number 4488-4491
Keywords artificial metalloenzymes, ruthenium, oxidation, piano stool complex, biotin-avidin technology
Abstract Based on the incorporation of biotinylated organometallic catalyst precursors within (strept)avidin, we have developed artificial metalloenzymes for the oxidation of secondary alcohols using tert-butylhydroperoxide as oxidizing agent. In the presence of avidin as host protein, the biotinylated aminosulfonamide ruthenium piano stool complex 1 (0.4 mol%) catalyzes the oxidation of sec-phenethyl alcohol at room temperature within 90 h in over 90% yield. Gel electrophoretic analysis of the reaction mixture suggests that the host protein is not oxidatively degraded during catalysis.
Publisher Elsevier
ISSN/ISBN 0022-328X
edoc-URL http://edoc.unibas.ch/dok/A5254485
Full Text on edoc No
Digital Object Identifier DOI 10.1016/j.jorganchem.2005.02.001
ISI-Number WOS:000232666000011
Document type (ISI) ArticleProceedings Paper
 
   

MCSS v5.8 PRO. 0.453 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
15/08/2020