Artificial metalloenzymes for asymmetric allylic alkylation on the basis of the biotin-avidin technology
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 116754
Author(s) Pierron, Julien; Malan, Christophe; Creus, Marc; Gradinaru, Julieta; Hafner, Ines; Ivanova, Anita; Sardo, Alessia; Ward, Thomas R.
Author(s) at UniBasel Ward, Thomas R.
Year 2008
Title Artificial metalloenzymes for asymmetric allylic alkylation on the basis of the biotin-avidin technology
Journal Angewandte Chemie International Edition
Volume 47
Number 4
Pages / Article-Number 701-5
Keywords allylic alkylation, artificial metalloenzymes, asymmetric catalysis, biotin, palladium
Abstract Palladium in the active site: The incorporation of a biotinylated palladium diphosphine within streptavidin yielded an artificial metalloenzyme for the title reaction (see scheme). Chemogenetic optimization of the catalyst by the introduction of a spacer (red star) between biotin (green triangle) and palladium and saturation mutagenesis at position S112X afforded both R- and S-selective artificial asymmetric allylic alkylases.
Publisher Wiley
ISSN/ISBN 1433-7851 ; 1521-3773
edoc-URL http://edoc.unibas.ch/dok/A5254470
Full Text on edoc No
Digital Object Identifier DOI 10.1002/anie.200703159
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/18181264
ISI-Number WOS:000252652200015
Document type (ISI) Journal Article
 
   

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