A Versatile Approach to the Solution-Phase Combinatorial Synthesis of Substituted Pyridines:  The Cobalt-Catalyzed Cyclotrimerization of Alkynes with a Nitrile
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 116720
Author(s) Braendli, Christof; Ward, Thomas R.
Author(s) at UniBasel Ward, Thomas R.
Year 2000
Title A Versatile Approach to the Solution-Phase Combinatorial Synthesis of Substituted Pyridines:  The Cobalt-Catalyzed Cyclotrimerization of Alkynes with a Nitrile
Journal Journal of Combinatorial Chemistry
Volume 2
Number 1
Pages / Article-Number 42-47
Keywords Cyclotrimerization (prepn. of pyridine library by cobalt-catalyzed soln.-phase cyclotrimerization of alkynes with nitrile); Alkynes; Nitriles Role: RCT (Reactant), RACT (Reactant or reagent) (prepn. of pyridine library by cobalt-catalyzed soln.-phase cyclotrimerization of alkynes with nitrile); Combinatorial library (pyridine library prepn. by cobalt-catalyzed soln.-phase cyclotrimerization of alkynes with nitrile); pyridine combinatorial library soln phase prepn; alkyne nitrile cobalt catalyzed
Abstract The cobalt-catalyzed trimerization of two alkynes and one nitrile was exploited to produce solution-phase libraries of pyridines. Upon addition of 2 equiv of a CO scavenger (i.e., an amine-N-oxide), the commercially available [CpCo(CO)2] proved to be an attractive catalyst, as the required reaction temperatures, side product formation (i.e., carbocycles), and oxygen sensitivity are moderate. Purification of the reaction mixture was performed with an acidic cation-exchange resin.
Publisher American Chemical Society
ISSN/ISBN 1520-4766 ; 1520-4774
edoc-URL http://edoc.unibas.ch/dok/A5254436
Full Text on edoc No
Digital Object Identifier DOI 10.1021/cc9900450
ISI-Number WOS:000084797600011
Document type (ISI) Article
 
   

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