We show that every automorphism of the group Gn := Aut(An) of polynomial automorphisms of complex affine n-space An = Cn is inner up to field automorphisms when restricted to the subgroup TGn of tame automorphisms. This generalizes a result of Julie Deserti who proved this in dimension n = 2 where all automorphisms are tame: TG2 = G2. The methods are different, based on arguments from algebraic group actions.