We have performed the first calculations to follow the evolution of all stable nuclei and their radioactive progenitors in a finely-zoned stellar model computed from the onset of central hydrogen burning through explosion as a Type 11 supernova. Calculations were done for 15 M-circle dot, 19 M-circle dot, 20 Mcircle dot, 21 Mcircle dot, and 25 Mcircle dot Pop I stars using the most recently available set of experimental and theoretical nuclear data, revised opacity tables, and taking into account mass loss due to stellar winds. Here, we focus on the nuclear inputs.