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Pitfalls in patient self-management of subcutaneous drug application : removal of rubber protection caps from ready-to-use syringes
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 107286
Author(s) Mengiardi, Seraina; Goepfert, Beat; Tsakiris, Dimitrios A; Hersberger, Kurt E
Author(s) at UniBasel Hersberger, Kurt
Tsakiris, Dimitrios
Göpfert, Beat
Mengiardi Nemec, Seraina
Year 2009
Title Pitfalls in patient self-management of subcutaneous drug application : removal of rubber protection caps from ready-to-use syringes
Journal European journal of clinical pharmacology
Volume 65
Number 10
Pages / Article-Number 1061-2
Abstract

Outpatient subcutaneous therapies are becoming more and more common, such as the use of low-molecular-weight heparins (LMWH) for prophylaxis or for the therapeutic treatment of thromboembolisms, multiple sclerosis, arthritis, anemia, or female infertility. Based on reports from patients and nurses indicating that some ready-to-use syringes require a concerted effort to remove the rubber protection cap, we decided to evaluate cap removal forces of commercial LMWH pre-loaded syringes as we were unable to find an ISO-norm from such syringes nor studies on this topic.

In conclusion, the mechanical cap-pull-off tests confirmed the results from self- and observer’s assessments, and important
differences between brands were observed. The pulloff forces correspond roughly to the force needed to hold a narrow-neck plastic flask containing 1–3 l of water by pinching the neck between a finger and thumb.Medical staff should be aware of these possibly crucial handling difficulties and their consequences for successful therapy and compliance.

Publisher Springer
ISSN/ISBN 0031-6970
edoc-URL http://edoc.unibas.ch/dok/A5253535
Full Text on edoc No
Digital Object Identifier DOI 10.1007/s00228-009-0681-0
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/19536529
ISI-Number WOS:000269851900014
Document type (ISI) Letter
 
   

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