Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 107264
Author(s) Hartmann, H; Eckert, A; Müller, W E
Author(s) at UniBasel Eckert, Anne
Year 1993
Title Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium
Journal Neuroscience letters
Volume 152
Number 1-2
Pages / Article-Number 181-4
Keywords DISSOCIATED NEURON, BRAIN AGING, DEPOLARIZATION, INTRACELLULAR CALCIUM, INOSITOLPHOSPHATE
Abstract

Age-related changes in Ca(2+)-homeostasis have been investigated in mechanically dissociated neurons from young and aged mice. In aged animals, basal intracellular calcium ([Ca2+]i) was significantly reduced and depolarization (KCl)-induced rise in [Ca2+]i was lower, probably as a result of increased activation of Ca(2+)-dependent mechanisms terminating Ca2+ influx. Additionally, depolarization-induced inositol-phosphate (IP) accumulation in aged animals was found to be significantly increased. Both findings suggest that Ca(2+)-dependent intracellular processes become more sensitive to Ca2+ in aged animals due to decreased Ca2+ availability.

Publisher Elsevier/North-Holland
ISSN/ISBN 0304-3940
edoc-URL http://edoc.unibas.ch/dok/A5253526
Full Text on edoc No
Digital Object Identifier DOI 10.1016/0304-3940(93)90513-K
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/8515874
ISI-Number WOS:A1993KX37600046
Document type (ISI) Journal Article
 
   

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