Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 107255
Author(s) Hartmann, H; Eckert, A; Müller, W E
Author(s) at UniBasel Eckert, Anne
Year 1994
Title Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity
Journal Biochemical and Biophysical Research Communications
Volume 200
Number 3
Pages / Article-Number 1185-92
Abstract

Besides the neurotoxic properties of beta-amyloid (beta A4), apolipoprotein E polymorphism seems to play an important role in the pathogenesis of sporadic Alzheimer's disease (AD). The calcium amplifying effect of beta A25-35 (the neurotoxic sequence of beta A4) in dissociated mouse brain neurons and human lymphocytes was nearly abolished by cholesterol (100-500 mumol/l). This effect may be related to the membrane stabilizing properties of cholesterol which could be confirmed by measurements of membrane fluidity. ApoE did not affect the Ca2+ amplifying effect of beta A25-35, but amplified the neuronal Ca2+ response significantly in a very low concentration (100nmol/l). The findings suggest a possible link between AD pathology and ApoE polymorphism by the calcium amplifying effect of ApoE itself as well as by the modulation of beta A4 neurotoxicity by cholesterol.

Publisher Elsevier
ISSN/ISBN 0006-291X
edoc-URL http://edoc.unibas.ch/dok/A5253517
Full Text on edoc No
Digital Object Identifier DOI 10.1006/bbrc.1994.1576
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/8185566
ISI-Number WOS:A1994NL38800003
Document type (ISI) Article
 
   

MCSS v5.8 PRO. 0.454 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
08/08/2020