β-amyloid peptide decreases membrane fluidity
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 107254
Author(s) Müller, W E; Koch, S; Eckert, A; Hartmann, H; Scheuer, K
Author(s) at UniBasel Eckert, Anne
Year 1995
Title β-amyloid peptide decreases membrane fluidity
Journal Brain research
Volume 674
Number 1
Pages / Article-Number 133-6
Abstract

The beta-amyloid peptide-25-35 (beta A25-35) decreases the fluidity of mouse brain membranes in a concentration-depending fashion. First effects were already seen at a beta A25-35 concentration of 100 nmol/1. beta-Amyloid peptide(1-40) was similarly active. beta A25-35 also decreases the fluidity of human lymphocyte membranes and of membranes from the cortex, hippocampus, striatum, and cerebellum of the rat, although the effects in the rat cerebellum are only weak. Scrambled beta A25-35 when investigated under similar conditions showed no effects on membrane fluidity. It is suggest that the effect on cellular calcium-signalling but also the neurotoxic properties of beta-amyloid might be the result of its concentration depending effects on membrane properties.

Publisher Elsevier
ISSN/ISBN 0006-8993
edoc-URL http://edoc.unibas.ch/dok/A5253516
Full Text on edoc No
Digital Object Identifier DOI 10.1016/0006-8993(94)01463-R
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/7773681
 
   

MCSS v5.8 PRO. 0.431 sec, queries - 0.000 sec ©Universität Basel  |  Impressum   |    
08/08/2020