Apoptosis of CD4+ T and natural killer cells in Alzheimer's disease
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 107171
Author(s) Schindowski, K; Peters, J; Gorriz, C; Schramm, U; Weinandi, T; Leutner, S; Maurer, K; Frölich, L; Müller, W E; Eckert, A
Author(s) at UniBasel Eckert, Anne
Year 2006
Title Apoptosis of CD4+ T and natural killer cells in Alzheimer's disease
Journal Pharmacopsychiatry
Volume 39
Number 6
Pages / Article-Number 220-8
Abstract

BACKGROUND: Immunotherapy appears to be a potent treatment against Alzheimer's disease (AD), but the mechanisms underlying neural-immune interaction are still not known. METHODS: Here, we determined cell death and distribution of lymphocyte subsets of peripheral blood mononuclear cells (PBMC) in AD and aging, e.g. T (CD4+ CD3+, CD8+ CD3+), B (CD19+) and NK (CD16++CD56+) cells. RESULTS: Increased apoptosis was found in CD4+ T and NK cells in AD, while in aging all subsets were affected. The expression of anti-apoptotic Bcl2 correlated with observed cell death in T-helper and B cells irrespective of dementia. The levels of Bcl2 in T-cells were significantly increased in mild AD. Apoptosis and Bcl2 levels were also elevated in the APP (751SL)xPS1 (M146L) transgenic mouse model. CONCLUSION: The mechanisms triggering apoptosis and activation of lymphocytes in AD appear therefore to be different than those in immunosenescence and possibly bear an important biomarker to monitor immunotherapy in AD.

Publisher Thieme
ISSN/ISBN 0720-4280
edoc-URL http://edoc.unibas.ch/dok/A5253457
Full Text on edoc No
Digital Object Identifier DOI 10.1055/s-2006-954591
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/17124644
ISI-Number WOS:000242635100005
Document type (ISI) Journal Article
 
   

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