Altered functional adaptation to attention and working memory tasks with increasing complexity in relapsing-remitting multiple sclerosis patients
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
ID 1055175
Author(s) Amann, Michael; Dössegger, Lea Sybil; Penner, Iris-Katharina; Hirsch, Jochen Gunther; Raselli, Carla; Calabrese, Pasquale; Weier, Katrin; Radü, Ernst-Wilhelm; Kappos, Ludwig; Gass, Achim
Author(s) at UniBasel Penner, Iris-Katharina
Kappos, Ludwig
Year 2011
Title Altered functional adaptation to attention and working memory tasks with increasing complexity in relapsing-remitting multiple sclerosis patients
Journal Human brain mapping : a journal devoted to functional neuroanatomy and neuroimaging
Volume 32
Number 10
Pages / Article-Number 1704-19
Keywords functional MRI, demyelinating, plasticity
Mesh terms Adaptation, Physiological, physiology; Adult; Analysis of Variance; Attention, physiology; Brain, physiopathology; Brain Mapping; Case-Control Studies; Disability Evaluation; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Memory, Short-Term, physiology; Middle Aged; Multiple Sclerosis, Relapsing-Remitting, physiopathology; Neuropsychological Tests; Oxygen, blood; Reaction Time, physiology; Young Adult
Abstract As attention, processing speed, and working memory seem to be fundamental for a broad range of cognitive performance, the present study on patients with mild forms of relapsing-remitting multiple sclerosis (RR-MS) focused on these domains. To explore subtle neuropsychological changes in either the clinical or fMRI domain, we applied a multistep experimental design with increasing task complexity to investigate global brain activity, functional adaptation, and behavioral responses to typical cognitive processes related to attention and working memory. Fifteen patients with RR-MS (mean age 38 years, 22-49 years, 9 females, mean disease duration 5.9 years (SD = 3.6 years), mean Expanded Disability Status Scale score, 2.3 (SD = 1.3) but without reported cognitive impairment), and 15 age-matched healthy controls (HC; mean age, 34 years, 23-50 years, 6 women) participated. After a comprehensive neuropsychological assessment, participants performed different fMRI experiments testing attention and working memory. In the neuropsychological assessment, patients showed only subtle reduction in learning and memory abilities. In the fMRI experiments, both groups activated the brain areas typically involved in attention and working memory. HC showed a linear in- or decrease in activation paralleling the changing task complexity. Patients showed stronger activation change at the level of the simple tasks and a subsequent saturation effect of (de-)activation at the highest task load. These group/task interaction differences were found in the right parahippocampal cortex and in the middle and medial frontal regions. Our results indicate that, in MS, functional adaptation patterns can be found which precede clinical evidence of apparent cognitive decline.
Publisher Wiley-Liss
ISSN/ISBN 1065-9471
Full Text on edoc No
Digital Object Identifier DOI 10.1002/hbm.21142
PubMed ID
ISI-Number WOS:000295539600016
Document type (ISI) Journal Article

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