Our mission is to resolve and understand biological mechanisms as they occur at the molecular-nanometer length scale i.e., Nanobiology. This challenges us to innovate beyond conventional bio-physical/-chemical and molecular biology approaches because the physicochemical properties of biomolecules (and their interactions) can be unexpectedly novel at the nanoscale. Our “bottom-up” view of biology is strongly complemented by our interdisciplinary expertise in quantitative nanoscience techniques, which we use to visualize, probe and manipulate biological systems under physiologically-relevant conditions at molecular length scales. Naturally, an important by-product of our work is in the realization/implementation of biological concepts for non-biological function. Our work has thus far focused on the key nanomachines of the cell nucleus in particular the nuclear pore complex and the nuclear lamina.