This project capitalizes on genome-wide human genetic information to identify and test memory-modulating drugs: In a large genome-wide association study of cognitive functions, we were able to identify several, potentially memory-modulating compounds. Three top candidates will be tested in clinical trials. The identification of memory-modulating drugs is key for improving treatment of disorders with memory dysfunctions, such as Alzheimer’s disease, schizophrenia, and posttraumatic stress disorder (PTSD).