Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense
JournalArticle (Originalarbeit in einer wissenschaftlichen Zeitschrift)
 
ID 1044025
Author(s) Gachet, M. S.; Kunert, O.; Kaiser, M.; Brun, R.; Zehl, M.; Keller, W.; Munoz, R. A.; Bauer, R.; Schuehly, W.
Author(s) at UniBasel Kaiser, Marcel
Brun, Reto
Year 2011
Title Antiparasitic compounds from Cupania cinerea with activities against Plasmodium falciparum and Trypanosoma brucei rhodesiense
Journal Journal of Natural Products
Volume 74
Number 4
Pages / Article-Number 559-66
Abstract In a survey of plants from Ecuador with antiprotozoal activity, Cupania cinerea was found to show significant in vitro activity against the Plasmodium falciparum K1 strain and Trypanosoma brucei rhodesiense. Subsequently, activity-guided isolation of the n-hexane and dichloromethane extracts from the bark of C. cinerea afforded two diterpene glycosides (1 and 2), named cupacinoside and 6'-de-O-acetylcupacinoside, and a lactonized triterpene bearing an oxepin moiety named cupacinoxepin (3), together with the known compounds scopoletin (4), caryophyllene oxide (5), two bisabolane sesquiterpenes (6 and 7), lichexanthone (8), gustastatin (9), lupenone (10), betulone (11), 17beta,21beta-epoxyhopan-3-one (12), taraxerol (13), and taraxerone (14). For compound 3, X-ray crystallography was employed to elucidate the relative configuration. For cupacinosides (1) and (2) and cupacinoxepin (3), in vitro activities against the P. falciparum K1 strain (IC(50)1, 1.3; 2, 1.8; and 3, 8.7 muM) and T. b. rhodesiense (IC(50)1, 4.5; 2, 15.8; and 3, 71.6 muM) were found. Cytotoxicity toward L-6 cells is discussed for all the compounds isolated.
Publisher American Society of Pharmacognosy
ISSN/ISBN 0163-3864 ; 1520-6025
edoc-URL http://edoc.unibas.ch/dok/A6002453
Full Text on edoc No
Digital Object Identifier DOI 10.1021/np100415m
PubMed ID http://www.ncbi.nlm.nih.gov/pubmed/21438586
ISI-Number WOS:000289742300003
Document type (ISI) Journal Article
 
   

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